Secrets

Secrets are unlocked by completing certain tasks or by meeting criteria in a playthrough. These can be viewed from the Main Menu by clicking on Stats.

= Secrets =
 * 001: Magdalene-Have 7 or more Heart containers in a single run
 * 002: Cain-Have 55 Pennies in a single run
 * 003: Judas-Defeat Satan
 * 004: The Womb-Defeat the Boss in The Depths 2
 * 005: The Harbingers-Defeat the Boss in The Depths 2
 * 006: A Cube of Meat and Bandage Ball-Defeat the Boss in The Depths 2
 * 007: The Book of Revelations-Defeat any of the Harbingers once
 * 008:
 * 009: The Nail-Defeat the Boss in The Womb 2 for the second time
 * 010:
 * 011:
 * 012:
 * 013: Monstro's Tooth-Defeat each regular Boss in The Basement
 * 014: Lil Chubby-Defeat each regular Boss in The Caves
 * 015: Loki's Horns-Defeat each regular Boss in The Depths
 * 022: The Book of Sin-Defeat each of the Seven Sins at least once (Counted over multiple playthroughs)
 * 027: The Halo-Defeat Mom with the item Bible
 * 028: Mr. Mega!-Destroy 10 Tinted Rocks (Counted over multiple playthroughs)
 * 037: Basement Boy-Beat The Basement without taking damage
 * 042: Eve-Go 2 floors in a row without getting heart pickups
 * 067: Samson-Beat 2 Consecutive levels without taking damage
 * 077: The Left Hand-Defeat Ultra Pride(or defeat The Lamb with Judas.)
 * 079: Azazel-Make 3 deals with the Devil in a single run
 * 080: Lazarus-Have 4 or more Soul Hearts +/ Black Hearts in a single run
 * 081: Eden-Defeat the Boss in The Womb 2 to unlock
 * 082: The Lost- Die as Isaac to a Muliboom on the Basement, by own bomb as Magdelene in the Caves, by Mom as Judas in the Depths, and by Satan's 2nd or 3rd form in Sheol.
 * 083: Dead boy: Do the Chest or Dark Room without taking damage.
 * 084:
 * 085: Lucky Rock-Destroy 100 rocks
 * 086: The Cellar-Beat all basement bosses.
 * 087: The Catacombs-Beat all caves bosses.
 * 101: Swallowed Penny- Beat Slow Roll Challenge.
 * 102: Robo Baby 2.0!-Beat Computer Savvy Challenge
 * 110: Cain's Other Eye-Do Boss Rush with Cain.
 * 134: A Blue Map-
 * 145: The Butter Bean-
 * 146: Little Baggy-
 * 151: Store Upgrade (Lv.1)-Donate 20 Pennies to the store
 * 158: Challenge #5 - The Tank-Unlock Magdelene.
 * 163: Challenge #10 - Cursed!-Unlock Magdelene.
 * 166: Challenge #20 - Purist-Defeat Mom.
 * 178:Become Lord of the Flies.
 * 110: Cain's Other Eye-Do Boss Rush with Cain.
 * 134: A Blue Map-
 * 145: The Butter Bean-
 * 146: Little Baggy-
 * 151: Store Upgrade (Lv.1)-Donate 20 Pennies to the store
 * 158: Challenge #5 - The Tank-Unlock Magdelene.
 * 163: Challenge #10 - Cursed!-Unlock Magdelene.
 * 166: Challenge #20 - Purist-Defeat Mom.
 * 178:Become Lord of the Flies.
 * 158: Challenge #5 - The Tank-Unlock Magdelene.
 * 163: Challenge #10 - Cursed!-Unlock Magdelene.
 * 166: Challenge #20 - Purist-Defeat Mom.
 * 178:Become Lord of the Flies.
 * 166: Challenge #20 - Purist-Defeat Mom.
 * 178:Become Lord of the Flies.
 * 178:Become Lord of the Flies.