Secrets are unlocked by completing certain tasks or by meeting criteria in a playthrough. These can be viewed from the Main Menu by clicking on Stats.
Secrets[]
- 001: Magdalene-Have 7 or more Heart containers in a single run
- 002: Cain-Have 55 Pennies in a single run
- 003: Judas-Defeat Satan
- 004: The Womb-Defeat the Boss in The Depths 2
- 005: The Harbingers-Defeat the Boss in The Depths 2
- 006: A Cube of Meat and Bandage Ball-Defeat the Boss in The Depths 2
- 007: The Book of Revelations-Defeat any of the Harbingers once
- 008:
- 009: The Nail-Defeat the Boss in The Womb 2 for the second time
- 010:
- 011:
- 012:
- 013: Monstro's Tooth-Defeat each regular Boss in The Basement
- 014: Lil Chubby-Defeat each regular Boss in The Caves
- 015: Loki's Horns-Defeat each regular Boss in The Depths
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- 022: The Book of Sin-Defeat each of the Seven Sins at least once (Counted over multiple playthroughs)
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- 027: The Halo-Defeat Mom with the item Bible
- 028: Mr. Mega!-Destroy 10 Tinted Rocks (Counted over multiple playthroughs)
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- 037: Basement Boy-Beat The Basement without taking damage
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- 042: Eve-Go 2 floors in a row without getting heart pickups
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- 067: Samson-Beat 2 Consecutive levels without taking damage
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- 077: The Left Hand-Defeat Ultra Pride(or defeat The Lamb with Judas.)
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- 079: Azazel-Make 3 deals with the Devil in a single run
- 080: Lazarus-Have 4 or more Soul Hearts +/ Black Hearts in a single run
- 081: Eden-Defeat the Boss in The Womb 2 to unlock
- 082: The Lost- Die as Isaac to a Muliboom on the Basement, by own bomb as Magdelene in the Caves, by Mom as Judas in the Depths, and by Satan's 2nd or 3rd form in Sheol.
- 083: Dead boy: Do the Chest or Dark Room without taking damage.
- 084:
- 085: Lucky Rock-Destroy 100 rocks
- 086: The Cellar-Beat all basement bosses.
- 087: The Catacombs-Beat all caves bosses.
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- 101: Swallowed Penny- Beat Slow Roll Challenge.
- 102: Robo Baby 2.0!-Beat Computer Savvy Challenge
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- 110: Cain's Other Eye-Do Boss Rush with Cain.
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- 134: A Blue Map-
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- 145: The Butter Bean-
- 146: Little Baggy-
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- 151: Store Upgrade (Lv.1)-Donate 20 Pennies to the store
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- 158: Challenge #5 - The Tank-Unlock Magdelene.
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- 163: Challenge #10 - Cursed!-Unlock Magdelene.
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- 166: Challenge #20 - Purist-Defeat Mom.
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- 178:Become Lord of the Flies.